Old blood may age the brains of young mice, and scientists are loser to understanding how. A protein located in the cells that form a barrier between the brain and blood could be the culprit.
If a similar mechanism occurs in humans, methods for countering the protein may hold promise for treating age-related brain decline.
H. Yousef et al. Aged blood inhibits hippocampal neurogenesis and activates microglia through VCAM1 at the blood-brain barrier. Published online January 3, 2018 at bioRxiv.org.