A team of researchers from the Washington University School of Medicine have discovered a way to stop brain tumor regeneration. The key to stopping tumor regeneration lies in the blocking and intervening in the works of brain tumor stem cells, which are the cause of regeneration. It seems that the stem cells can be prevented from making the SOX2 protein with the help of another protein, CDC20. Conducting an experiment on mice the scientists observed the brain tumor regeneration was stopped by eliminating CDC20. This led to the incapacity of the tumor stem cells to produce SOX2 and so they no longer had the power to form tumors.
According to Dr. Kim the rate of growth in several tumors which lacked CDC20 dropped 95% when compared with tumors which had a normal level of CDC20. Now the researchers will concentrate on finding a way to block the CDC20 protein. One possible way to do this is through RNA (ribonucleic acid) interference, a method which is already used in treating some types of cancers and other illnesses.
According to Dr. Kim the rate of growth in several tumors which lacked CDC20 dropped 95% when compared with tumors which had a normal level of CDC20. Now the researchers will concentrate on finding a way to block the CDC20 protein. One possible way to do this is through RNA (ribonucleic acid) interference, a method which is already used in treating some types of cancers and other illnesses.
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